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KMID : 0352720030270030129
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Journal of Ginseng Research
2003 Volume.27 No. 3 p.129 ~ p.134
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Cytotoxicity of Compound K (IH-901) and Ginsenoside R/sub /h2/, Main Biotransformants of Ginseng Saponins by Bifidobacteria, against Some Tumor Cells
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Shin JE
Park EK/Kim EJ/Hong YH/Lee KT/Kim DH
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Abstract
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When ginsenoside R/sub /b1/ and R/sub b2/ were anaerobically incubated with human fecal microflora, these ginsenosides were metabolized to compound K (IH-901). When ginsenoside R/sub g3/ was anaerobically incubated with human fecal microflora, the ginsenoside R/sub g3/ was metabolized it to ginsenoside R/sub h2/. Among ginsenosides, IH-901 and 20(S)-ginsenoside R/sub h2/ exhibited the most potent cyotoxicity against tumor cells: 50% cytotoxic concentrations of IH-901 in the media with and without fetal bovine serum (FBS) were 27.1-31.6 μM and 0.1-0.61 μM, and those of 20(S)-ginsenoside R/sub h2/ were 37.5->50 and 0.7-7.1 μM, respectively. The cytotoxic potency of ginsenosides was IH-901>20(S)-ginsenoside Rh/sub h2/》20(S)-ginsenoside R/sub g3/>ginsenoside R/sub b1/(equation omitted)R/sub b2/.
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